By default, after install wine or its helper like CrossOver, PlayOnLinux… Wine can really mess up with your system file associations at the moment. Some file extension was associated with Open with winebrowser.exe automatically. I faced with this inconvenience problem when open a pdf file by enter button or double click in file manager. The wine will creating a lot of file dependencies to start a new wine.exe instance, it costs time and garbage files per folder where you store the pdf file.